аЯрЁБс>ўџ %'ўџџџ$џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџьЅСs П jbjbР Р ЊkЊkџџџџџџ]–––––––ЦЦЦЦЦ в Ц•ъъъъъъъъъRTTTTTT,єs`€–ъъъъъ€"––ъъъ"""ъ.–ъ–ъRЊИ––––ъR"0"R––Rо )]gДЦЦ RThe recent discovery of genes encoding DNA repair, recombination, and cell cycle control proteins has opened a window for understanding how biological systems cope with DNA damage. This window has been opened further as information from several completely sequenced genomes gives us a larger picture of the number of proteins that repair, protect, or otherwise care for the genome. Cellular responses to DNA damage include cell cycle checkpoints and repair processes that act coordinately, prior to, during and after DNA replication, to maintain genomic stability. Cellular machinery involved in protecting and repairing DNA consists of proteins and protein complexes that constitute multiple biochemical pathways, many of which we are just beginning to understand. Knowledge concerning these proteins is crucial to the understanding of human health, as defects in related processes have been directly associated with disease susceptibility, particular cancer proneness. Our Biology Program at Lawrence Livermore National Laboratory integrates functional genomics, mammalian genetics, protein biochemistry, molecular biology, structure determination and computational approaches to understand the mechanisms of DNA repair. Links to specific projects, groups or scientific areas…   §B*€ЯаЬЭ §§§§§§§€ЯаЬЭ Аа/ Ар=!А"А# $ %АV0S@у@01"P2€Hч@€/ ?.џў?ЉD/ ?.џў?<ЈOLп0R@NКџš`ЈLпN^NuBЏ x  Pp0g*€ќAш`"P"Q i№g i\HWШџъf/hџњNuNVHч80<?AњмИB˜QШџќ$nYONКџІ(gЄUO/HzтьNК@Aњтт0Ÿ"D"QAњоО Љ#zоВv&j&S&k&SGыжУ<<Iњм` Kg@аУ( f*(UO// NКъ0gвУJ)f†|EжУXKRF`КEњуn4МEњоv/?<џџЉ5QЫџіLпxN^ _XONа:слfЎNVHч8Aњу40М<<єIњлдYONКўЬ gŠ&@UO/HzтNКd>Оzтg<:сў&S'zно:$nvGыжУ8<g:жУ+ f(UO/ Bg4@ИFmИGl4@?NКšJgB [(@ёџ(NormalCJmH <A@ђџЁ<Default Paragraph Fontџџџџ џџ   $+ФЭ$,џџ David Wilson;dmw iii:DMWIII:LLNL items:WebSite:Repair Group:Repair.introDavid Wilson III:dmwiii:DMWIII:LLNL items:WebSite:Repair Group:Repair.introџ@€ЮЮќЪ:99ЮЮ5 @@GTimes New Roman5€Symbol3 Arial3Times"qˆаh@Є(†œу; Бєƒ$„ЅРДД€r0dкУџџџThe recent discovery of genes encoding DNA repair, recombination, and cell cycle control proteins has opened a window for understanding how biological systems cope with DNA damage. This window appears to have been only narrowly opened, as information from David WilsonDavid Wilson IIIаJ3gLHЧ хˆ"хˆаJ3f:HЧ хˆ"хˆаB3/ ? boxes are still available at the Employee Store. Call 2-9035 for more information. ========================================================================== NewsOnLine is also available in the newsgroup llnl.NewsOnLine. To unsubscribe from the NewsOnLine electronic mailing list, use the Auto-Registration Service (autoreg) available on the Web at http://www.llnl.gov/llnl_only/labnet/autoreg.cgi or send a message to autoreg@llnl.gov asking to be removed from the NewsOnLine mailing list. Make sure you specify the list name (NewsOnLine) and include either your official ID or your employee number. ========================================================================== From ???@??? Wed Nov 24 10:25:42 1999 Received: from pierce.llnl.gov (pierce.llnl.gov [128.115.18.253]) by poptop.llnl.gov (8.8.8/LLNL-3.0.2/pop.llnl.gov-5.1) with ESMTP id JAA10144; Wed, 24 Nov 1999 09:33:13 -0800 (PST) Received: from popcorn.llnl.gov (popcorn.llnl.gov [128.115.18.67]) by pierce.llnl.gov (8.8.8/LLNL-3.0.2/llnl.gov-5.0) with ESMTP id JAA04528; Wed, 24 Nov 1999 09:15:38 -0800 (PST) Received: from aisdb4.llnl.gov (aisdb4.llnl.gov [128.115.33.93]) by popcorn.llnl.gov (8.8.8/LLNL-3.0.2/pop.llnl.gov-5.1) with ESMTP id JAA28294; Wed, 24 Nov 1999 09:15:37 -0800 (PST) Received: (from oracle@localhost) by aisdb4.llnl.gov (8.8.8+Sun/8.8.8) id JAA19605; Wed, 24 Nov 1999 09:15:37 -0800 (PST) Date: Wed, 24 Nov 1999 09:15:37 -0800 (PST) Message-Id: <199911241715.JAA19605@aisdb4.llnl.gov> X-Mailer: PL/SQL OraMail 1.1 (LLNL Oracle PL/SQL->Mail Service) To: trr@bbrp.llnl.gov, lindstrom1@llnl.gov, wilson61@llnl.gov, thomas5@llnl.gov From: "SALAZAR, PRISCILLA E" Subject: TOPS Material Request Order 9311231 Content-Type: text X-UIDL: e915a9f713aeb3c410e5323c37e989ce -------------------------------------------------------- FYI, -------------------------------------------------------- Material Request: 9311231 Employee Number: 77A033 Creator Name..: Sўџ р…ŸђљOhЋ‘+'Гй0`ˆ˜ЄМШи є  ( 4@HPX'The recent discovery of genes encoding DNA repair, recombination, and cell cycle control proteins has opened a window for understanding how biological systems cope with DNA damage. This window appears to have been only narrowly opened, as information fromhe  David WilsonscoaviNormaliDavid Wilson IIIery3viMicrosoft Word 8.0y@М e@(zŸЬН@Xžгя9ПБє-- ----- -------------- 1 VWR 15160-795 EA 1 369.0000 VWR SLIDE WARMER, Group Code Lines Total Est Price ---------- ------ --------------- 1 $ 369.00 ------ -------------- Totals: 1 $ 369.00 From ???@??? Wed Nov 24 10:30:12 1999 To: "SALAZAR, PRISCILLA E" From: "David M. Wilson III" Subject: Re: TOPS Material Request Order 9311231 Cc: Bcc: X-Attachments: Message-Id: In-Reply-To: <199911241715.JAA19605@aisdb4.llnl.gov> I believe this was sent to me in error. dmwiii >-------------------------------------------------------- >FYI, > >-------------------------------------------------------- > Material Request: 9311231 > >Employee Number: 77A033 Creator Name..: SALAZAR, PRISCILLA E Extn: 28858 >Employee Number: 886925 Requester Name: THOMAS, CYNTHIA B Extn: 26290 >Dept Ctrl No...: S13875 Place Date....: >Delivery Info..: THOMAS/SALAZA B361 RM1662 > >TO VIEW ORDER IN DETAIL, USE THE FOLLOWING WEB ADDRESS: >------------------------------------------------------- >https://www-ais.llnl.gov/llnl_plsql_la_web_rq/rq.rq_get_mtl_rqst_info_pr67?p_mr_no=9311231 > > > Acct No Pct Auth > ------- ------ ------ > 6217-41 100 970544 > > >Ln No Vend Vendor Part Number UOM Qty Unit Price Stat Description >----- ----- ------------------------- --- ------ ---------- ----- -------------- > 1 VWR 15160-795 EA 1 369.0000 VWR SLIDE WARMER, > > > > Group Code Lines Total Est Price > ---------- ------ --------------- > 1 $ 369.00 > ------ -------------- > Totals: 1 $ 369.00 From ???@??? Wed Nov 24 10:25:42 1999 Received: from pierce.llnl.gov (pierce.llnl.gov [128.115.18.253]) by poptop.llnl.gov (8.8.8/LLNL-3.0.2/pop.llnl.gov-5.1) with ESMTP id HAA21115 for ; Wed, 24 Nov 1999 07:49:47 -0800 (PST) Received: from giants.llnl.gov (giants.llnl.gov [128.115.249.1]) by pierce.llnl.gov (8.8.8/LLNL-3.0.2/llnl.gov-5.0) with ESMTP id HAA09255 for ; Wed, 24 Nov 1999 07:49:47 -0800 (PST) Received: from himalaya.nas.edu (himalaya.nas.edu [144.171.1.23]) by giants.llnl.gov (8.9.3/8.9.3/LLNL-4.0) with ESMTP id HAA03991 for ; Wed, 24 Nov 1999 07:49:46 -0800 (PST) Received: from smtpmta.nas.edu (smtpmta.nas.edu [144.171.1.40]) by himalaya.nas.edu (8.9.1/8.9.1) with SMTP id KAA18613 for ; Wed, 24 Nov 1999 10:46:14 -0500 (EST) Received: by smtpmta.nas.edu(Lotus SMTP MTA v4.6.3 (778.2 1-4-1999)) id 85256833.0056B6DE ; Wed, 24 Nov 1999 10:47:09 -0500 X-Lotus-FromDomain: NAS From: "Barbara Orton" To: "David M. Wilson III" Message-ID: <85256833.0056B621.00@smtpmta.nas.edu> Date: Wed, 24 Nov 1999 10:49:03 -0500 Subject: Re: Manu. No. 99-4127 Mime-Version: 1.0 Content-Disposition: inline Content-Type: text/plain; charset=us-ascii X-UIDL: 2baaf23637ec92c59b30de4ec4cc1834 Dear Dr. Wilson, The decision letter on your manuscript (ms. no. 99-4127) was faxed to you on November 19, and the manuscript was returned to yўџ еЭеœ.“—+,љЎDеЭеœ.“—+,љЎ0ь hp€ˆ˜  ЈАИ Р Ь'LLNLceкb The recent discovery of genes encoding DNA repair, recombination, and cell cycle control proteins has opened a window for understanding how biological systems cope with DNA damage. This window appears to have been only narrowly opened, as information from Title˜ 6> _PID_GUID'AN{9A3DC980-A59F-11D3-A90D-00059AA01019} replay. Unfortunate news, but we make needed changes and try again elsewhere. I was more in need of the reviews than the manuscript, so no worries about its apparent disappearance. It'll turn-up somewhere. Sincerely, dmwiii >Dear Dr. Wilson, > >The decision letter on your manuscript (ms. no. 99-4127) was faxed to you on >November 19, and the manuscript was returned to you the same day by Federal >Express. I am sorry to inform you that your manuscript was not accepted. >Please let us know if the manuscript has still not arrived by the end of the day >today; if necessary, we will try to track down the delivery in order that we may >return your figures to you. I apologize for the inconvenience. > >Sincerely yours, > >Barbara J. Orton >Editorial Coordinator >PNAS From ???@??? Sun Nov 21 12:34:23 1999 To: Felton_Jim From: "David M. Wilson III" Subject: hadi justification Cc: Bcc: X-Attachments: Message-Id: jim, please read and comment (this one is VERY important - sensitive foreign national): TimesThis position has entailed the performance of experimental research aimed at defining the molecular and biochemical details of processes involved in protecting mammalian cells from the deleterious effects of ionizing radiation and other DNA-damaging agents. Dr. Masood Hadi has brought relevant talents to the Program in the areas of DNA repair and genetic recombination. During his first year plus, Masood has helped identify genetic variation inDNA repair genes within the human population that imparts a reduced-function phenotype. In addition, Masood has been heavily involved in interacting with DNA repair, computational, structural and genomic investigators to perform basic science research and to identify novel genes towards better understanding issues of human disease susceptibility. Masood has completed and submitted one research manuscript in this area, and is near the completion of at least two others. A third (additional) year beyond the initial two-year commitment would prove valuable both to the Program in terms of efficiently completing the research projects at hand and to Masood in terms of his career development and quest to become a more well-rounded scientist. thanks, dmwiii From ???@??? Wed Nov 24 10:25:42 1999 Received: from pierce.llnl.gov (pierce.llnl.gov [128.115.18.253]) by poptop.llnl.gov (8.8.8/LLNL-3.0.2/pop.llnl.gov-5.1) with ESMTP id WAA02050 for ; Tue, 23 Nov 1999 22:15:03 -0800 (PST) Received: from giants.llnl.gov (giants.llnl.gov [128.115.249.1]) by pierce.llnl.gov (8.8.8/LLNL-3.0.2/llnl.gov-5.0) with ESMTP id WAA27662 for ; Tue, 23 Nov 1999 22:15:03 -0800 (PST) Received: from uclink4.berkeley.edu (uclink4.Berkeley.EDU [128.32.25.39]) by giants.llnl.gov (8.9.3/8.9.3/LLNL-4.0) with ESMTP id WAA05654 for ; Tue, 23 Nov 1999 22:15:02 -0800 (PST) Received: from [128.32.128.99] (kosh-51b-3.Berkeley.EDU [128.32.128.99]) by uclink4.berkeley.edu (8.8.8/8.8.8) with ESMTP id WAA24869 for ; Tue, 23 Nov 1999 22:15:02 -0800 (PST) Mime-Version: 1.0 Message-Id: X-mailer: Eudora Pro 4.0.1 Macintosh Da ўџџџ ўџџџўџџџ !"#ўџџџ§џџџ&ўџџџўџџџўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџRoot Entryћ}о~]пЕ{џћњ{ЕіuѓЎПџџЧџџяПћЛS?ЗщЏЙЉкџЋ{?{іџџџџџџџџ РFБ7W~џ+ў?€štчЌ9П(€Sїї1TableпЛ?ŸWЗО\5{ЛыЏЭПnпьы'пyf~УП]nэwwžџTЗлљ?ЗцoзПћџЛџџџџџџџџzяџ/SДћЯŠ3џЏії73ЮПћЛ:іЯln§ь{>џЖЖuZ ј2_;WordDocumentџдНпџЋЋЎїТ~[ПџѓћзgОЎ{Їщ2–7яіЗП7џQѕџџџџџџџџqџgћПєлжаS?ЏНxiЫѓ'ЫКџѕп§яŽ>іwђ.uЏы˜SummaryInformationџН_ПЛЯф]ўЯбяп§z›ѓ§{џvџ(џџџџНџлџЇƒѓчєйъяхлПљџv7ѕуЕЖwяmДпПњлїчїу{Zє§DocumentSummaryInformationўкпwЇ?ЏЇ8џџџџџџџџџџџџS7эпГ›ћ3_ћћќлџ=џјїuгџ?В_џ§л~n_oџыzН5џњџCompObjїџNЉккюпеџчєџпѓbџ>>Ko]WПўџџпінџћз5mДПэ?нЛџћПЗџџџџџџџџџџџџ{гкwSџѕo}oџwкЫыї}їXОЏц{ўЋ?qзОо}ЛјПЗЗїћн ?љ?j-ЛОлќs{п}7zїЇкзїіџпўъяџЯяОTяёГ?vѕq}ћЏзџчџџџџџџџџџџџџїNў{;џљzЏщлЯoЮћыїМФџЗж66fџZЯљџ§k{йš#—їѕїОпЗ?ДџџqеsКaП[їяћџЗюїѕ›<џ)Бћїџж?џ^гmG~г ПzќлџџяГПo+_uыљ›имŸЛ_sЧ7{ћџџџџџџџџџџџџ<мœhД;gћяEѕі7пЛ+’}Цїя›}V?џ~Лѕ~ыН7пЯлyїяwћ?Пs{Пўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџўџџџџџ РFMicrosoft Word DocumentўџџџNB6WWord.Document.8nner (but probably not a whole turkey) at our place later. > >Cheers, > >Jan From ???@??? Wed Nov 24 12:42:48 1999 To: ashroden@hotmail.com From: "David M. Wilson III" Subject: Cc: Bcc: X-Attachments: Message-Id: ash, been trying to touch base with rob, but i believe his server is down. 1. my friend will be joining us for t-giving feast, and was wonder